Hi, @A MyCOPDTeam Member, I guess you've figured out by now, when someone mentions the dreaded S word a dropdown informs you that you are important and you don't need to resort to self harm. You don't have to pay any attention to it.
I just dropped in to tell you I like what you say about how far you've come in dealing with COPD and all that goes with it. 'My brain lies to me. It tells me I am nothing.' Those are powerful words. Thanks for sharing your experiences with us.

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A MyCOPDT...

Hi Louise.
I am not a Rocket Scientist. In fact, I am surprised how most things actually stay on the ground. But I think you ARE ON to something.

One of the MAIN ingredients in our meds is called AntiCholinergics (ACHs). Click on the blue link here for Trelegy to read about it. For other medical issues, the effect of ACH is actually used in Anti-Depressant treatments. It is a nervous system chemical the body normally makes and balances well. But too much ACH can also suspected as causes of Dementia. That plays out as a being in a Depressed state for me - from personal experience.

The problem I have raised before is that these ACH ingredients are in a lot of stuff we don't often think about - like OTC meds and cough syrups. Then you have a "stacking effect" that NO one is measuring. Here an article from Harvard Med School: https://www.health.harvard.edu/mind-and-mood/tw...
They ARE the rocket scientists. But don't be surprised if your Doc brushes this all aside. The ACHs are the best meds we have so far for COPD.
be Well

Two types of drugs you may want to avoid for the sake of your brain - Harvard Health

https://www.health.harvard.edu/mind-and-mood/two-types-of-drugs-you-may-want-to-avoid-for-the-sake-of-your-brain

I don't think depression is linked to Trelegy. It's medicine is for the lungs. I believe depression comes from the COPD and the fact of how it affects us. Depression is brought on by the COPD and you should talk with your doctor about some anti depressant.

I have lived through three severe depressions in my life. The first time was when I was 13. I tried to kill myself. The second when I was in my forties, I was suicidal, but I managed to ask for help. That was one of the hardest things I have ever had to do. The last time they told me I was in a mixed state. I was angry and suicidal at the same time. I lashed out at the people who loved me and were trying to help me. Here is what I learned and what I remind myself of if I'm ever feeling depressed:

My brain lies to me. It tells me I am nothing. It tells me the people I love would be better off without me. It tells me nobody could love me. But I answer back: I love my loved ones and they love me. If I were to hurt myself, I would hurt them to depths and in ways I can't even imagine. I love, I am loved. I will get through this rather than cause them pain.

I don't know if this will help anyone else. But I hope so.

I take Trelegy and have anxiety and depression real bad.